Congratulations to our clients on their recent publications!

Dr. Chen-Kang Chang and team studied the effects of branched-chain amino acids (BCAA), arginine, and citrulline supplementation on central fatigue. Between periods of intensive Taekwando exercise, they measured the premotor reaction time of athletes who were given amino acid (AA) supplements versus those who received a placebo. They also measured the ratios of free tryptophan to BCAA, since tryptophan is a precursor to serotonin– a molecule that may be responsible for lethargy when present in high levels.

This paper was published in the Journal of the International Society of Sports Nutrition. To see how AA supplementation affected central fatigue, click here to read about it!

Dr. Chang and team also studied the effects of AA supplementation on tennis players’ perceptual motor performance. They provided the subjects with either the AA supplements or a placebo one hour before starting tennis matches. They measured the accuracy and consistency that the players hit the tennis balls with, along with the players’ tryptophan levels.

This second paper was published in the Scandinavian Journal of Medicine & Science in Sports. Click here to see how AA supplementation affected tennis players’ perceptual motor performance!

Mediomics Bridge-It Tryptophan Assay Kit was used in the study to measure the concentration of plasma free tryptophan.

Mediomics is proud to serve such innovative clients and wishes them the best of luck in their future projects!

Congratulations to our clients on their December publication in BMC Systems Biology!

Dr. Matias Zurbriggen and team set out to create a system that models the detection of the border between two distinct cell populations. They designed a network where L-Tryptophan diffuses across the border from its sender/receiver cell population to the adjacent population. In turn, a second signaling protein, Interleukin-4 (Il-4), is released in a dose-dependent manner. Once Il-4 travels back to the sender/receiver cell, it activates expression of a fluorescent reporter protein at the border between the two populations. They measured the fluorescence at the border, in response to increased levels of Tryptophan/Il-4. Research like this has serious implications in the field of tissue engineering.

Mediomics Bridge-It Tryptophan Assay Kit was used in the study to measure the concentration of Tryptophan.

Mediomics is proud to serve such innovative clients and wishes them the best of luck in their future projects!

To see more details about how their system worked, check out the full article here.

Congratulations to our clients for their publication in the FASEB Journal!

The role of Pannexin 3 in bone development has not yet been studied in vivo. Dr. Lee and team’s recent research provides evidence of the crucial roles of Panx3 in vertebrate skeletal development in vivo.

Mediomics’ Bridge-It cAMP designer Assay kit was used to measure cAMP levels in cells.

To find out more about Dr. Lee’s research, access the link here.

Mediomics is proud to serve such innovative clients in research and wishes them the best of luck in their future projects!

Featured Publication:  Pfizer Oncology Team identifies potential therapeutic targets for lung cancer published in the EMBO Journal in May, 2015.

Mediomics wishes to congratulate Dr. Stephen Dann and his team for their important discovery of the reciprocal regulation between extracellular Met uptake and epigenetic state in malignant cells. They identified Lat1, an amino acid transporter, as a downstream biomarker of EZH2 activity and demonstrated the critical role of Lat1 in supporting tumor growth.

Mediomics is proud to serve such innovative clients in cancer research and wishes them the best of luck in their future projects!

To read more about Dr. Dann’s research, access the link here.

Congratulations to our clients in Japan on their February publication in Nature Medicine!

Dr. Keizo Nishikawa and team identified various metabolic processes involved in osteoclastogenesis, including the increased production of SAM. The research provides knowledge towards developing new therapeutic strategies for a variety of bone disorders.

Mediomics’ Bridge-It S-adenosyl Methionine Assay Kit was used in the study to detect SAM in osteoclast precursors and osteoclasts.

Mediomics is proud to serve such innovative clients and wishes them the best of luck in their future projects!

To read more about Dr. Nishikawa’s research, access the link here.

Congratulations to our clients on their March publication in PLOS One!

Dr. Chen-Kang Chang and team studied the effects of branched chain amino acid and arginine supplementation on physical and mental fatigue. They measured how the performance of the sprint activity after 2 consecutive days differed between players given the amino acid supplementation versus those who received the placebo.

Mediomics Bridge-It Tryptophan Assay Kit was used in the study to measure the concentration of plasma free tryptophan.

Mediomics is proud to serve such innovative clients and wishes them the best of luck in their future projects!

To see how the supplementation affected overall performance, check out the full article here.