Featured Publication: A synthetic mammalian network to compute population borders based on engineered reciprocal cell-cell communication

Congratulations to our clients on their December publication in BMC Systems Biology!

Dr. Matias Zurbriggen and team set out to create a system that models the detection of the border between two distinct cell populations. They designed a network where L-Tryptophan diffuses across the border from its sender/receiver cell population to the adjacent population. In turn, a second signaling protein, Interleukin-4 (Il-4), is released in a dose-dependent manner. Once Il-4 travels back to the sender/receiver cell, it activates expression of a fluorescent reporter protein at the border between the two populations. They measured the fluorescence at the border, in response to increased levels of Tryptophan/Il-4. Research like this has serious implications in the field of tissue engineering.

Mediomics Bridge-It Tryptophan Assay Kit was used in the study to measure the concentration of Tryptophan.

Mediomics is proud to serve such innovative clients and wishes them the best of luck in their future projects!

To see more details about how their system worked, check out the full article here.